Experimental study of cytotoxic T lymphocyte associated molecule-4Ig for prevention of mice autoimmune hepatitis
10.3321/j.issn:1000-5404.2001.03.016
- VernacularTitle:CTLA-4Ig预防小鼠自身免疫性肝炎的实验研究
- Author:
Yang LUO
1
;
Fei HAO
;
Yu-Ming WANG
;
Bai-Yu ZHONG
;
Shu-Qian TANG
Author Information
1. Southwest Hospital Third Military Medical University
- From:Journal of Third Military Medical University
2001;23(3):300-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of cytotoxic T lymphocyte associated molecule-4Ig(CTLA-4Ig) in the prevention of C57BL/6 mice autoimmune hepatitis. Methods The C57BL/6 mice were intraperitoneally immunized with C57BL/6 mice liver-specific protein in complete Freund's adjuvant. At the same time CTLA-4Ig were given to observe the pathologic alteration of C57BL/6 mice liver. Results With the increase of time of immunization, the results in the treatment group were similar to those of the control group; but inflammatory cell infiltration, hepatic cell swelling, focal necrosis and severe hepatocyte damage were found in the pathologic model group. There was a significant difference between the pathologic model group and control one. Conclusion Autoimmune hepatitis of C57BL/6 mice can be effectively prevented by CTLA-4Ig.
