Effects of glucagon-like peptide 2 on recovery of small intestinal epithelia from radiation injury in mice
10.3321/j.issn:1000-5404.2001.03.014
- VernacularTitle:胰高血糖素样肽-2对放射损伤小鼠肠上皮恢复的影响
- Author:
Jun-Dong ZHU
1
;
Yong-Ping SU
;
Tian-Min CHENG
Author Information
1. 第三军医大学
- From:Journal of Third Military Medical University
2001;23(3):293-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of glucagon-like peptide 2 (GLP-2) on recovery of small intestinal epithelia from radiation injury in mice. Methods Mice received a single 8 Gy dose of total body irradiation from 60Co gamma ray followed by treatment with GLP-2 or vehicle. DNA and protein content in small intestinal mucosa were measured, and small intestine was processed for histological examination with light microscope and scanning electron microscope. Results Small intestinal mucosal DNA and protein content, villus height, and villus number significantly decreased in irradiated mice, partial villus tips were ulcerated. GLP-2 administration caused increase in DNA and protein content, villus height, and villus number as compared with irradiated control group. Meanwhile, the villus tips were lack of ulceration. Conclusion GLP-2 can promote recovery of small intestinal epithelia from radiation injury in mice.
