Effects of irradiation and W11-a12 on anion-selective channel of mouse peritoneal macrophage
10.3321/j.issn:1000-5404.2001.03.013
- VernacularTitle:电离辐射对小鼠腹腔巨噬细胞阴离子通道活动的影响及康复新对其的作用
- Author:
Chong-Xiang SHU
1
;
Ben-Lan YE
;
Tian-Min CHENG
;
Jia-Si XIAO
Author Information
1. 第三军医大学
- From:Journal of Third Military Medical University
2001;23(3):290-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of irradiation and W11-a12，a kind of repair-promoting drug，on anion-selective channel in membranes of mouse peritoneal macrophage. Methods The activity of anion-selective channel was recorded from cell-attached patches with patch clamp techniques． Results The effects of irradiation on anion-selective channel in membranes of peritoneal macrophage included：①decreasing the mean number of activated channels by the presence of zymosan; ②prolonging the mean time from stimulus to the opening of channels; ③depressing the opening of channels by decreasing open-state probability，shortening open-time and prolonging close-time． The effects of irradiation could partly be depressed by W11-a12. Conclusion Irradiation will depress the anion-selective channel of peritoneal macrophage, which may be an important way to depress the function of macrophage．
