Pathogenesis of Anti-MAG Antibody Associated with Demyelinating Peripheral Neuropathy: Expression of Anti-MAG Antibody in Ebstein-Barr Virus Transformed Lymphocytes of Umbrical Cord.
- Author:
Kwang Woo LEE
1
;
Ji Soo KIM
;
Sung Hyun LEE
;
Keun Ho LEE
;
In Soo JU
Author Information
1. Department of Neurology, Seoul National University, Korea.
- Publication Type:Original Article
- MeSH:
Antibodies;
B-Lymphocytes;
Chromatography, Thin Layer;
Glycolipids;
Herpesvirus 4, Human;
Humans;
Lymphocytes*;
Myelin Sheath;
Paraproteinemias;
Peripheral Nerves;
Peripheral Nervous System Diseases*
- From:Journal of the Korean Neurological Association
1995;13(1):39-46
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It is not unconimm that the monoclonal gammopathies occur in patients with demyelinating peripheral neuropathy. The IgM.-protein from those patients reacted with peripheral nerve myelin, which was first identified as the MAG (myelinassociated glycoprotein). In this study the authors tried to understand the pathogenetic mechanism of anti-MAG antibod by studying the expression of the anti MAG antibody in Epstein-Barr virus transformed lymphocytes of umbrical cord. The positive bands for anti-NMG antibody were found in 10 out of 320 sera of peripheral neuropathies by the thin layer chromatography of the glycolipids from bovine peripheral myelin. The positive anti-MAG expressions were found in 5 of 31 supernatant wells from EB virus transformed lymphocytes of umbrical cords, which tended to. Develop the antibody activity in the supernatants cultured more than ten days. The study indicates. In part that the anti-MAG antibody may be occurred by the autoimmune mechanism as the antibodies are expressed m the EB virus transformed lymphocytes which have never been exposed to foreign antigens so far However the automimune mechanism can be supported more by knowing the mcreased frequency of CD5 positive B cells in cases with high titer of anti-MAG antibodies.
