Telomerase activity and P53 expression in Non-small cell lung cancer and their significances
10.3321/j.issn:1000-5404.2001.02.006
- VernacularTitle:非小细胞肺癌组织中端粒酶活性和P53表达及其意义
- Author:
Tong-Hua MEI
1
;
Li-Ping ZHANG
;
Yue-Quan JIANG
Author Information
1. Chongqing Medical University
- From:Journal of Third Military Medical University
2001;23(2):138-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significances of telomerase activity and P53 expression in Non-small cell lung cancer (NSCLC). Methods The activity of telomerase in cancerous tissues was detected by PCR-ELISA, and the expression of P53 protein was detected by S-P method. Results The telomerase activity and P53 expression were significantly higher in NSCLC tissues than in normal lung tissues. The telomerase activity and P53 expression had close association with the differentiation of cancer cells and lymph node metastasis. Conclusion It is very valuable to measure telomerase activity and P53 expression in studying the initiation and progression of NSCLC.
