Review of arsenic trioxide effect on solid cancer

VernacularTitle:三氧化二砷抗实体肿瘤的研究概况
Author: Chen ZHANG ¹ ; Chang-Quan LING
Author Information

1. Chinese Medicine Changhai Hospital Second Military Medical University
Keywords: arsenic trioxide; solid cancer; apoptosis; review literature
From: Academic Journal of Second Military Medical University 2003;24(4):440-443
CountryChina
Language:Chinese
Abstract: Clinical trials have demonstrated that arsenic trioxide(As2O3) was effective in the treatment of acute promyelocytic leukemia(APL), based on this facts, studies have been carried out to study its role in the treatment of solid cancer at home and abroad. Primary in vitro study showed that As2O3 could treat the cancer of digestive system such as hepatoma, esophageal carcinoma, gastric cancer, and the cancer of urinary and reproductive system such as cervical cancer, ovarian cancer, bladder transitional carcinoma,as well as lung cancer, breast cancer, prostate cancer, etc. The mechanism of As2O3 actions may be the induction of apoptosis, the inhibition of growth and the promotion of differentiation of solid cancers. This article reviews on As2O3 in treatment of solid cancer.