Replacing dog cervical esophagus with polyurethane stent covered with collagen-chitosan sponge
- VernacularTitle:可降解复合人工食管重建犬颈段食管的实验研究
- Author:
Xiong QIN
1
;
Zhi-Fei XU
;
Xue-Wei ZHAO
;
Hong-Can SHI
;
Jian-Hua ZHOU
;
Yao-Chang SUN
;
Kang SUN
;
Xiang-Yang GAO
Author Information
1. Changzheng Hospital Second Military Medical Univ ersity
- Keywords:
artificial esophagus;
esophageal reconstruction;
biodegra dable materials;
polyurethane;
collagen;
chitosan
- From:
Academic Journal of Second Military Medical University
2002;23(10):1128-1133
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To replace esophageal defects with artificially composed biodegradable materials and non-biodegradable materials. Met hods: A two-layered tube consisting of a collagen-chitosan sponge and an inner polyurethane stent was used to replace 5 cm esophageal segmental defect s in 15 dogs. The inner polyurethane stent was removed endoscopically at weekly intervals from 2 or 4 weeks. Results: Partial regeneration of es ophageal epithelia was observed in 5 dogs at week 2, and progressing constricti on occurred and the dogs became unable to swallow within 1 month. In the 10 dog s that the polyurethane stent was removed at week 4, regenerated esophageal tiss ue successfully replaced the defects, and complete epithelization was observed 1 month after surgery. Complete regeneration of esophageal mucosa structures, inc luding mucosal smooth muscle and mucosal glands were observed 3 months after surgery, and partial regeneration of esophageal muscle tissue was also observed 6 months after surgery. Conclusion: Our artificial prosthesis i n reconstruction of the cervical esophagus segment in dogs is feasible. Through temporary polyurethane tube, collagen-chitosan sponge provides a three-dimensi onal structure suitable for the regeneration and sufficient degradation time for the complete regeneration of esophagus.
