Analysis of relationship between P27, P53 and PCNA expression and its clinical significance

VernacularTitle:P27、P53和增殖细胞核抗原在胃癌组织中的表达及其临床意义
Author: You-Qun ZHU ¹ ; Mei-Zhen WAN ; You-Fu CAO ; Jian-Ming ZHENG ; Yue-Di HU ; Yong-Juan SHI ; Zheng-Yao SHE
Author Information

1. Changzhou Tumor Hospital
From: Academic Journal of Second Military Medical University 2001;22(5):450-452
CountryChina
Language:Chinese
Abstract: Objective: To investigate the relationship between P27，P53 and PCNA expression in human gastric carcinoma tissues and clinicopathological parameters. Methods: The expression of P27，P53 and PCNA in 62 human gastric carcinoma tissues was examined with immunohistochemistry SP method. Results: Positive rates of P27，P53 and PCNA expression were 37.1％, 40.4%，83.9％. P27 expression was related with Bormann type, infiltrative depth, lymph node and distant metastasis and clinical stage. P53 expression was related with sex of patients, distant metastasis and clinical stage. PCNA expression was related with age of patients and infiltrative depth of tumor. P27 positive expression group was higher than negative group as to 5-year survival. P27 expression was in reverse relation with PCNA expression. Conclusion: The expression of P27, P53 and PCNA may be regarded as an important marker in judging malignant degree of gastric carcinoma,distant metastasis and prognosis.