Effects of esculentoside A on production of IL-1 and TNF by rabbit synovial cells
10.3321/j.issn:0258-879X.2001.05.008
- VernacularTitle:商陆皂苷甲对兔滑膜细胞产生IL-1和TNF的影响
- Author:
Qin-Yue ZHENG
1
;
Hui-Feng WANG
;
Xiang-Min ZHENG
;
Zhen-Yu XIAO
;
Yang-Hua YI
Author Information
1. Second Military Medical University
- From:
Academic Journal of Second Military Medical University
2001;22(5):425-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the influence of esculentoside A（EsA） on production of IL-1 and TNF by rabbit synovial cells induced by LPS. Methods: levels of IL-1 and TNF in the supernatant of rabbit synovial cell were determined by examining proliferation of thymic cells and by bioassay L929 cells as target cells, respectively. Results: EsA in 5-40 μg/ml could significantly inhibit the production of IL-1 and TNF from rabbit synovial cells induced by LPS. Conclusion: EsA can inhibit the production of IL-1 and TNF from synovial cells. It suggests that EsA may play a role in improving the rheumatoid arthritis.
