Pharmacokinetics of diclofenac sodium microemulsion in human
10.3321/j.issn:0258-879X.2001.04.023
- VernacularTitle:双氯芬酸钠人体内的药代动力学
- Author:
Ying LU
1
;
Xue-Tao JIANG
;
Ren-Jie ZENG
;
Ying LIU
Author Information
1. Second Military Medical University
- From:
Academic Journal of Second Military Medical University
2001;22(4):364-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the pharmacokinetics of diclofenac sodium microemulsions in human. Methods: According to the crossover design, each volunteer was orally given diclofenac sodium microemulsion and diclofenac sodium tablet. The serum concentrations were determined by RP-HPLC with UV-detector. The concentration-time data were analyzed using 3P87 Pharmacokinetic Program and the pharmacokinetics parameters were compared by paired t-test. Results: It was found that diclofenac sodium in serum was linear within the range of 50-8 000 μg/L. The minimum detection concentration was 30 μg/L. The mean rate of recovery was (100.55±1.56)%. After a single oral dose, AUC0～∞ were 5.563，7.891 μg*h/ml, MRT 5.489， 5.387 h for dispersible diclofenac sodium microemulsion and tablet respectively. Conclusion: Absorption progress of diclofenac sodium microemulsion in human may be special.
