The change of coronary circulating TNF-α level in patients with coronary heart disease after PTCA and its significance
10.3321/j.issn:0258-879X.2001.02.026
- VernacularTitle:冠心病患者PTCA后冠脉循环TNF-α水平的改变及其临床意义
- Author:
Rong-Zeng DU
1
;
Zong-Gui WU
;
Zuo HUANG
;
Gao-Zhong HUANG
;
Guo-Yuan ZHANG
Author Information
1. Changzheng Hospital Second Military Medical Uni versity
- From:
Academic Journal of Second Military Medical University
2001;22(2):185-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of percutaneous tr ansluminal coronary angioplasty (PTCA) on coronary circulating tumor necrosis fa ctor-α (TNF-α) activity. Methods: Plasma TNF-α levls were measured with radioimmunoassay and bioactive assay respectively. Result s: Plasma TNF-α activity in femoral artery (AO) was significantly incr eased immediately after PTCA [(15.86±3.75) U/ml vs (41.32±4.36) U/ml, P<0.01], and plasma TNF-α activity in coronary sinus was remarkably incre ased immediately after PTCA [(16.72±4.14) U/ml vs (65.61±6.25) U/ml, P<0.01]. There was no change in plasma TNF-α activity in AO 24 h after PT CA [(18.32±5.12) U/ml vs (15.86±3.75) U/ml, P>0.05]. Conclu sion: The increase in plasma TNF-α activity after PTCA may be associat ed with the injury of coronary artery caused by PTCA, suggesting that TNF-α ma y be involved in the coronary occlusion and the development of coronary restenos is after PTCA.