The efficacy of naftopidil in treatment of mild-to-moderate essential hyperten sion

VernacularTitle:萘哌地尔治疗原发性高血压的临床研究
Author: Gao-Zhong HUANG ¹ ; Rong-Zeng DU ; Chun LIANG ; Jin-Ming CHEN ; Zong-Gui WU
Author Information

1. Changzheng Hospital Second Military Medical Universit y
From: Academic Journal of Second Military Medical University 2001;22(2):170-172
CountryChina
Language:Chinese
Abstract: Objective: To investigate the efficacy and safety of naftopidil on patients with mild-to-moderate essential hypertension. Methods: A prospective, open study was performed in patients with hyp ertension. Forty patients were administered naftopidil for 8 weeks. Results:BP decreased significantly 2 weeks after administration an d reached to its trough at week 4. The magnitudes were 2.28 kPa (17.1 mmHg) and 1.43 kPa (10.7 mmHg) for SBP and DBP, respectively. The effect lasted to the end of experiment. HR had no change.The total effective rate was 82.05%.There was n o significant change in liver and renal function and electrocardiograph. Conclusion: Naftopidil has a stable hypotensive effect and the complia nce is good.