Effects of pravastatin on atherosclerotic plaque and cardiovascular events in pa tients with coronary disease
10.3321/j.issn:0258-879X.2001.02.018
- VernacularTitle:普伐他汀对冠状动脉硬化斑块及心血管事件的影响
- Author:
Zong-Gui WU
1
;
Jin-Ming CHEN
;
Zuo HUANG
;
Jun ZHAO
;
Gao-Zhong HUANG
;
Jia-You ZHANG
;
Wei SONG
Author Information
1. Changzheng Hospital Second Mil itary Medical University
- From:
Academic Journal of Second Military Medical University
2001;22(2):161-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of pravastatin o n atherosclerotic plaque and cardiovascular events. Methods: Fifty- seven patients with coronary artery disease (44 male and 13 female, 58.4±11.3 y ears) were randommized into pravastatin and control groups. The patients in prav astatin group were administered 10 mg of pravastatin from the night of coronary angiography day. After 7.3 months (mean) of follow-up, plasma lipid parameters and coronary angiograph were repeated. Results: (1) A favorable effect on plasma lipid parameters was found. After administration, total choles terol(TC), low density lipoprotein cholesterol (LDL-C) and triglyceride(TG) red uced by 15.0% (P<0.01), 18.0% (P<0.01) and 6.0%, respectively. High den s ity lipoprotein cholesterol(HDL-C) increased by 10.6%. However, in control grou p, TC and LDL-C showed a tendency to reduce, but no significant difference was found between those of pre- and post-administration. (2)There was no significa nt difference in luminal diameter between pre- and post-administration in both groups. (3) Cardiovascular events in pravastatin group was significantly lower than those in control (P<0.05). (4) Pravastatin had no significant effect on HR, BP and left ventricular ejection fraction in both groups. Conclusio n: Pravastatin can stabilize coronary atherosclerostic plaque and reduce the incidence of cardiovascular events by improving plasma lipid parameters.
