Early-onset sepsis in a neonatal intensive care unit in Beni Suef, Egypt: bacterial isolates and antibiotic resistance pattern.
10.3345/kjp.2013.56.8.332
- Author:
Sameh Samir FAHMEY
1
Author Information
1. Department of Pediatrics, Beni Suef University Faculty of Medicine, Beni Suef, Egypt. ssfahmey34@yahoo.com
- Publication Type:Original Article
- Keywords:
Drug Resistance;
Newborn;
Sepsis
- MeSH:
Accounting;
Ampicillin;
Bacteria;
Cephalosporins;
Cloaca;
Drug Resistance;
Drug Resistance, Microbial;
Enterobacter;
Enterobacter cloacae;
Escherichia coli;
Humans;
Imipenem;
Infant;
Infant, Newborn;
Intensive Care, Neonatal;
Klebsiella;
Klebsiella pneumoniae;
Mothers;
Organothiophosphorus Compounds;
Pneumonia;
Retrospective Studies;
Risk Factors;
Sepsis;
Staphylococcus aureus;
Vancomycin
- From:Korean Journal of Pediatrics
2013;56(8):332-337
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To identify the frequency of bacterial isolates in early-onset neonatal sepsis (EONS) and their antimicrobial resistance pattern. METHODS: A retrospective study of EONS was conducted at the Beni Suef University Hospital from September 2008 to September 2012. A case of EONS was defined as an infant who had clinical signs of infection or who was born to a mother with risk factors for infection, and in whom blood culture obtained within 72 hours of life grew a bacterial pathogen. RESULTS: Of 673 neonates screened, there were 138 positive blood cultures (20.5%) (confirmed EONS). Of the recovered isolates, 86.2% were gram-negative pathogens. Klebsiella pneumoniae (42.8%), Enterobacter cloacae (22.5%), and Escherichia coli (13.8%) were the commonest isolated organisms. The most common gram-positive microorganism was Staphylococcus aureus accounting for only 12 isolates (8.7%). All Klebsiella isolates and 93% of Enterobacter isolates were resistant to ampicillin. Gram-negative pathogens had the maximum overall sensitivity to imipenem, cefepime, and ciprofloxacin; whereas, gram-positive isolates were most susceptible to vancomycin, imipenem, and piperacillin. CONCLUSION: K. pneumoniae was the predominant causative bacteria of EONS followed by E. cloacae and E. coli. There was a high resistance to ampicillin. Imipenem had the maximum overall activity against the causative bacteria. Continuous surveillance is needed to monitor the changing epidemiology of pathogens and antibiotic sensitivity.
