Patterns of care for patients with nasopharyngeal carcinoma (KROG 11-06) in South Korea.
10.3857/roj.2015.33.3.188
- Author:
Soo Yoon SUNG
1
;
Min Kyu KANG
;
Chul Seung KAY
;
Ki Chang KEUM
;
Sung Hwan KIM
;
Yeon Sil KIM
;
Won Taek KIM
;
Ji Yoon KIM
;
Jin Hee KIM
;
Sung Ho MOON
;
Yong Chan AHN
;
Young Taek OH
;
Hong Gyun WU
;
Chang Geol LEE
;
Woong Ki CHUNG
;
Kwan Ho CHO
;
Moon June CHO
;
Jin Hwa CHOI
Author Information
1. Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. yeonkim7@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Nasopharyngeal neoplasms;
Patterns of care;
Radiotherapy;
Korea
- MeSH:
Appointments and Schedules;
Chemotherapy, Adjuvant;
Cisplatin;
Diagnostic Imaging;
Drug Therapy;
Electrons;
Humans;
Korea*;
Magnetic Resonance Imaging;
Nasopharyngeal Neoplasms;
Radiation Oncology;
Radiotherapy;
Retrospective Studies
- From:Radiation Oncology Journal
2015;33(3):188-197
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the patterns of care for patients with nasopharyngeal carcinoma (NPC) in South Korea. MATERIALS AND METHODS: A multi-institutional retrospective study was performed (Korean Radiation Oncology Group [KROG] 11-06) on a total of 1,445 patients from 15 institutions. RESULTS: Of the 1,445 patients, more than half were stages III (39.9%) and IV (35.8%). In addition to patterns of care, we also investigated trends over time with the periods 1988-1993, 1994-2002, and 2003-2011. The frequencies of magnetic resonance imaging and positron emission tomography-computed tomography were markedly increased in the third period compared to previous 2 periods. Concurrent chemoradiation (CCRT) was performed on 894 patients (61.9%), neoadjuvant chemotherapy on 468 patients (32.4%), and adjuvant chemotherapy on 366 patients (25.3%). Of stage II-IV patients, CCRT performed on 78.8% in 2003-2011 compared to 15.0% in 1988-1993. For patients treated with CCRT, cisplatin was the most commonly used agent in 81.3% of patients. Over the periods of time, commonly used radiotherapy (RT) techniques were changed from 2-dimensional RT (1988-1993, 92.5%) to 3-dimensional RT (2003-2011, 35.5%) or intensity-modulated RT (IMRT; 2003-2011, 56.5%). Median RT doses given to primary tumors, high-risk lymphatics, and low-risk lymphatics were 70.0 Gy, 58.1 Gy, and 48.0 Gy, respectively. Adoption of IMRT increased the dose per fraction and escalated total radiation dose. CONCLUSION: Assessment of the patterns of care for NPC patients in South Korea demonstrated that management for NPC including diagnostic imaging, treatment regimen, RT techniques and dose schedule, advanced in accordance with the international guidelines.
