Clinical outcomes of stereotactic body radiotherapy for spinal metastases from hepatocellular carcinoma.
10.3857/roj.2015.33.3.217
- Author:
Eonju LEE
1
;
Tae Gyu KIM
;
Hee Chul PARK
;
Jeong Il YU
;
Do Hoon LIM
;
Heerim NAM
;
Hyebin LEE
;
Joon Hyeok LEE
Author Information
1. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hee.ro.park@gmail.com
- Publication Type:Original Article
- Keywords:
Stereotactic body radiotherapy;
Spinal metastases;
Hepatocellular carcinoma
- MeSH:
Appointments and Schedules;
Carcinoma, Hepatocellular*;
Disease-Free Survival;
Follow-Up Studies;
Fractures, Compression;
Humans;
Neoplasm Metastasis*;
Radiosurgery*;
Retrospective Studies;
Survival Rate
- From:Radiation Oncology Journal
2015;33(3):217-225
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the outcomes of patients with spinal metastases from hepatocellular carcinoma (HCC), who were treated by stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: This retrospective study evaluated 23 patients who underwent SBRT from October 2008 to August 2012 for 36 spinal metastases from HCC. SBRT consisted of approximately 2 fractionation schedules, which were 18 to 40 Gy in 1 to 4 fractions for group A lesions (n = 15) and 50 Gy in 10 fractions for group B lesions (n = 21). RESULTS: The median follow-up period was 7 months (range, 2 to 16 months). Seven patients developed grade 1 or 2 gastrointestinal toxicity, and one developed grade 2 leucopenia. Compression fractures occurred in association with 25% of the lesions, with a median time to fracture of 2 months. Pain relief occurred in 92.3% and 68.4% of group A and B lesions, respectively. Radiologic response (complete and partial response) occurred in 80.0% and 61.9% of group A and B lesions, respectively. The estimated 1-year spinal-tumor progression-free survival rate was 78.5%. The median overall survival period and 1-year overall survival rate were 9 months (range, 2 to 16 months) and 25.7%, respectively. CONCLUSION: SBRT for spinal metastases from HCC is well tolerated and effective at providing pain relief and radiologic response. Because compression fractures develop at a high rate following SBRT for spinal metastases from primary HCC, careful follow up of the patient is required.
