A Case of Pulmonary Alveolar Proteinosis with Spontaneous Resolution.
10.4046/trd.2007.63.3.294
- Author:
Seung Bum NAM
1
;
Kwang Young PARK
;
Ho Jin LEE
;
Jae Wook JUNG
;
Yoon Hee CHOI
;
Hyo Seok KIM
;
Cheol Hyeon KIM
;
Jae Cheol LEE
Author Information
1. Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea. jclee@kcch.re.kr
- Publication Type:Case Report
- Keywords:
Pulmonary alveolar proteinosis;
Spontaneous resolution
- MeSH:
Biopsy;
Bronchioles;
Bronchoalveolar Lavage;
Diagnosis;
Granulocyte-Macrophage Colony-Stimulating Factor;
Lung;
Pulmonary Alveolar Proteinosis*;
Respiratory Insufficiency
- From:Tuberculosis and Respiratory Diseases
2007;63(3):294-298
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pulmonary alveolar proteinosis is a rare disorder that is characterized by the abundant accumulation of surfactant-derived material within the alveolar spaces and distal bronchioles. Although the findings of homogenous ground-glass opacities overlaid by thickened septa, which form a "crazy paving" pattern on high-resolution computed tomography, can assist in making a diagnosis, a lung biopsy is usually required. This disorder has a variable clinical course, from spontaneous resolution to respiratory failure and death. While a whole lung lavage has been the standard treatment since the early 1960s, GM-CSF therapy has been attempted based on the recently suggested pathogenetic mechanism. We report a case of pulmonary alveolar proteinosis that resolved spontaneously after an open lung biopsy.
