Effect of the Vacuolation of Helicobacter Pylori

Author: Li SHI ¹ ; Xiaohua HOU ; Suiqiong YI ; Jinkun ZHANG
Author Information

1. The Digestive Disease Institute of PLA, Nang Fang Hospital,
From: Journal of Huazhong University of Science and Technology (Medical Sciences) 2001;21(2):97-99
CountryChina
Language:Chinese
Abstract: Cytotoxic test in vitro combined with cytochemical stain, fluorescent stain, transmission electronmicrograph was used to study the vacuolated effect by helicobacter pylori (H.pylori) (Toxin＋) and its pathological mechanism. 78.26 % patients with peptic ulcer associated with H.pylori was infected with H.pylori (Toxin＋), while 42.86 % patients with gastritis was infected with H.pylori (Toxin＋). It was positive in vacuole with acridine orange and acid phosphatase stain. Transmission electronmicrograph of vacuole revealed the presence of abounding membrane. There was a closed relationship between infection with H.pylori (Toxin＋) and peptic ulcer disease. The vacuole induced by H.pylori (Toxin＋) was autophagosome, which was pathological phenomenon induced by toxin.