Effect of Cardiopulmonary Bypass on Beta Adrenergic ReceptorAdenylate Cyclase System on Surfaces of Peripheral Lymphocytes
- Author:
Ailin LUO
1
;
Yuke TIAN
;
Shiao JIN
Author Information
1. Tongji Hospital Tongji Medical University
- Keywords:
cardiopulmonary bypass;
adrenergic beta receptor-adenylate cyclase;
cellular immunity
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2000;20(1):77-78
- CountryChina
- Language:Chinese
-
Abstract:
The experimental results showed that the level of CAMP, the ratio of cAPM to cGMP,IL-2R expression and IL-2 production in vitro in lymphocytes immediate and 2 weeks after cardiopulmonary bypass (CPB) were significantly lower than those before anesthetics in the patients undergoing cardiac surgery with CPB. These findings suggested that CPB could cause serious damage to adrenergic beta receptor-adenylate cyclase system on circulating lymphocytes surfaces,which might be one of the mechanisms resulting in immunosuppression after open heart surgery with CPB.
