Effects of Extremely Low Doses of Arginine Vasopressin on the Renal Function in Two-kidney One Clip Goldblatt Hypertensive Rabbit.
- Author:
Byung Chan KIM
1
;
Sook Jeong LEE
;
Xun CUI
;
Suhn Hee KIM
;
Kyung Woo CHO
Author Information
1. Department of Physiology, Medical School, Jeonbug National University, Jeonju, Korea.
- Publication Type:Original Article
- Keywords:
Arginine vasopressin;
Antidiuretic hor- mone;
Renal hypertension;
Renal function;
Rabbit;
Renin secretion rate;
Renal arterial infusion
- MeSH:
Arginine Vasopressin*;
Arginine*;
Blood Pressure;
Hemodynamics;
Hypertension;
Hypertension, Renal;
Hypertension, Renovascular;
Kidney;
Plasma;
Rabbits;
Water
- From:Korean Journal of Nephrology
2000;19(4):624-636
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It has been suggested that arginine vasopressin is involved in the acute, but not chronic, regulation of blood pressure. It is still debatable on the role of arginine vasopressin in the development and maintenance of high blood pressure, especially in renal hypertension. This study was performed to examine antidiuretic and renal hemodynamic effects of extremely low doses of arginine vasopressin and the modification of the effects in the early phase of two-kidney one clip Goldblatt hypertensive rabbits. Very low doses(up to 10-20mole/kg/min) of intrarenal arginine vasopressin induced decreases in urine volume, free water clearance, glomerular filteration rate and renal plasma flow(CPAH). The renal effects of arginine vasopressin were dose-dependent. These data indicate that the sensitivity of the kidney to decrease urine volume in response to arginine vasopressin is at least three orders of magnitude higher than previously reported. The renal effects of arginine vasopressin was significantly attenuated by the pretreatment of V2-receptor antagonist. The antidiuretic and renal hemodynamic effects elicited by very low doses of intrarenal arginine vasopressin were suppressed in the contralateral unclipped kidney of two-kidney, one clip Goldblatt hypertensive rabbits. These data suggest that the renal functions can be regulated normally by an extremely low concentration of plasma arginine vasopressin and the regulatory mechanism controlled by the ultralow plasma levels of arginine vasopressin is suppressed in the early phase of two-kidney, one clip Goldblatt hypertension.
