No Evidence for an Association between Dopamine D2 Receptor Polymorphisms and Tardive Dyskinesia in Korean Schizophrenia Patients.
- Author:
Young Min PARK
1
;
Seung Gul KANG
;
Jung Eun CHOI
;
Yong Ku KIM
;
Seung Hyun KIM
;
Ji Young PARK
;
Leen KIM
;
Heon Jeong LEE
Author Information
1. Department of Psychiatry, Inje University College of Medicine, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Tardive dyskinesia;
Dopamine receptor;
Schizophrenia;
Polymorphism;
Association
- MeSH:
Antipsychotic Agents;
Dopamine;
Dyskinesias;
Haplotypes;
Humans;
Movement Disorders;
Polymorphism, Single Nucleotide;
Receptors, Dopamine;
Receptors, Dopamine D2;
Schizophrenia
- From:Psychiatry Investigation
2011;8(1):49-54
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. Dopaminergic activity in the nigrostriatal system have been proposed to be involved in development of TD and dopamine D2 receptors (DRD2) has been regarded as a candidate gene for TD because the antipsychotics have potent antagonism DRD2. This study was aimed to find the relationship between DRD2 gene and antipsychotic-induced TD. METHODS: We evaluated whether 5 DRD2 single nucleotide polymorphisms (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) are associated with antipsychotic-induced TD in 263 Korean schizophrenia patients with (n=100) and without TD (n=163) who were matched for antipsychotic drug exposure and other relevant variables. Haplotype analyses were also performed. RESULTS: None of 5 polymorphisms were found to be significantly associated with TD and with TD severity as measured by Abnormal Involuntary Movement Scale. Overall haplotype (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) frequency was also not significantly different between TD and non-TD groups, although one rare haplotype (I-D1-T-G-A1) showed significantly different frequency between TD and non-TD groups (2.7% vs. 8.5%, respectively, p=0.031). CONCLUSION: The present study does not support that DRD2 gene may be involved in TD in the Korean population, although further studies are warranted.
