Progress of phosphohistone H3 in tumors
10.3760/cma.j.issn.1006-9801.2019.01.016
- VernacularTitle:磷酸化组蛋白H3在肿瘤中的研究进展
- Author:
Xiaohong LI
1
;
Rong FU
;
Yutao ZHANG
Author Information
1. 四川省自贡市第一人民医院病理科 643000
- Keywords:
Neoplasms;
Phosphohistone H3;
Mitosis
- From:
Cancer Research and Clinic
2019;31(1):66-68
- CountryChina
- Language:Chinese
-
Abstract:
Phosphohistone H3 (PHH3) is one of the five newly discovered nucleocardial histones. PHH3 with other histones constitute the main protein components in chromatin in eukaryotic. For it reached the maximum value in G2 phase and M phase with mitosis, so it was considered as a specific nuclear fission marker. At present, PHH3 has been proved to be very useful to determine the nuclear fission images of tumor cells, and to distinguish the nuclear fission images from apoptotic bodies and nuclear fragments. This paper reviews the research status of PHH3 in tumors.
