Effect of metformin on prognosis of patients with breast cancer:a Meta-analysis
10.3760/cma.j.issn.1006-9801.2019.01.009
- VernacularTitle:二甲双胍对乳腺癌患者预后影响的Meta分析
- Author:
Yimeng GUO
1
;
Jing YANG
;
Hongxia YAN
;
Zhiying HAO
Author Information
1. 山西省肿瘤医院药学部
- Keywords:
Breast neoplasms;
Metformin;
Prognosis;
Meta-analysis
- From:
Cancer Research and Clinic
2019;31(1):41-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the effect of metformin on the prognosis of patients with breast cancer. Methods The databases including PubMed, Embase, Cochrane Library, ClinicalTrials, ScineceDirect, CBM, CNKI, Wanfang database and VIP were electronically searched from their inception to April 18, 2018 to collect the studies about the effect of metformin on the prognosis of patients with breast cancer. According to the inclusion and exclusion criteria, two reviewers screened the literatures independently, extracted data and assessed methodological quality. The meta-analysis was performed by using Review Manager 5.1 software. Results A total of 2 randomized controlled trials and 17 cohort studies involving 8929 patients were included. The meta-analysis showed that compared with control group, the metformin group marked increase in pathologic complete remission (pCR) rate (RR=2.97, 95％CI 1.80-4.90, P<0.01) and cancer-specific survival (CSS) time was prolong significantly (RR= 0.70, 95％CI 0.57-0.87, P= 0.001). Subgroup analysis of the overall survival (OS) time according to different areas showed that the metformin group's OS time was prolong significantly (Europe and America studies subgroup: RR=0.75, 95％CI 0.65-0.86, P<0.01; Asian studies subgroup:RR=0.48, 95％CI 0.37-0.61, P<0.001). Conclusion The use of metformin is positive for the prognosis of patients with breast cancer, it may improve the pCR rate, CSS and OS time of patients.
