Fatty acid metabolism and tumor occurrence, development and metastasis
10.3760/cma.j.issn.1006-9801.2018.12.016
- VernacularTitle:脂肪酸代谢与肿瘤的发生、发展和转移的关系
- Author:
Wei HUANG
1
;
Zhongping CHENG
Author Information
1. 同济大学附属杨浦区中心医院妇产科
- Keywords:
Neoplasm metastasis;
Neoplasm occurrence;
Neoplasm development;
Fatty acid synthesis;
Fatty acid decomposition
- From:
Cancer Research and Clinic
2018;30(12):879-882
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the relationship between fatty acid metabolism and tumor has become a hot topic and widely recognized.In tumor cell,fatty acid metabolism is important to its growth and metastasis.About synthesis,fatty acid can participate in the synthesis of phospholipids on the membrane of cancer cells and take part in important signal transduction pathways,such as PI3K-AKT-mTOR;in fatty acid catabolism,tumor cells can produce ATP to maintain its growth by β-oxidation;what's more,it could be kept redox homeostasis by producing nicotinamide adenine dinucleotide phosphate hydrogen (NADPH).So,anabolism and catabolism of fatty acid may promote occurrence and development of tumors,but the mechanisms are unclear.This review highlights the effects of fatty acid metabolism on the occurrence,development and metastasis of tumors.
