Antagonistic effect of platelet-rich plasma on photo-aged skin in rat
10.3760/cma.j.issn.1671-0290.2018.06.019
- VernacularTitle:富血小板血浆对大鼠光老化皮肤的改善作用
- Author:
Wenbo WU
1
;
Minliang CHEN
;
Yanqiu WU
;
Guanglei LI
Author Information
1. 解放军总医院第四医学中心烧伤整形科
- Keywords:
Platelet-rich plasma;
Light;
Cell aging;
Skin;
Rats;
Photoageing
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2018;24(6):445-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of platelet-rich plasma (PRP) on photoaging skin of rat.Methods F344 rats were used as model animals and skin photoaging model was established by UV irradiation.The model animals were divided into 5 groups:group A was injected with activated PRP (A-PRP);group B was injected with inactive PRP (N-PRP);group C was injected with normal saline;group D was irradiated only with UV;Four weeks after the injection,the appearance and histological characteristics of the rat's skin were evaluated.Results Compared with group C and group D,the wrinkles and skin color in group A and group B were significantly improved.Histological observation showed that the histological features of group A and group B were significantly better than that of group C and D (P＜0.01).The thickness of dermis in group A was higher than that in group B (P＜0.05).There was no significant difference between groups C and D (P＞0.05).The thickness of dermis in group E was significantly higher than that in group C (P＜0.01).Conclusions Injection of PRP can improve the appearance and histological features of photo-aged skin in rats.A-PRP is better than N-PRP.
