Correlation study of serum homocysteine with renal function and coagulation indexes in hypertensive patients
10.3760/cma.j.issn.1009-9158.2018.12.011
- VernacularTitle:高血压患者同型半胱氨酸与肾功能及凝血指标的相关性研究
- Author:
Yanfen XING
1
;
Yongwei LI
Author Information
1. 450002,河南中医药大学第二附属医院检验科
- Keywords:
Hypertension;
Homocysteine;
B-Microglobulin;
Retinol binding protein;
Cystatin C;
D-Dimer;
Fibrinogen degradation product
- From:
Chinese Journal of Laboratory Medicine
2018;41(12):952-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to investigate the correlation of serum homocysteine with renal function and coagulation indexes in hypertensive patients .Methods Through retrospective design , 224 hypertensive patients and 212 healthy subjects who sought medical service in Henan Province Hospital of TCM during 2017 to 2018, were divided into four groups according to hypertension and homocysteine level, that was normotensive normal Hcy group (103 patients), normotensive high Hcy group (109 patients), hypertensive normal Hcy group (115 patients), and hypertensive high Hcy group ( 109 patients ) .Serum homocysteine , serum lipid and renal function indexes were detected by automatic biochemical analyzer .The level of coagulation indexes were detected by automatic coagulation analyzer and platelet was tested by automatic blood cell analyzer .Comparisons of variables between four groups were evaluated by one way ANOVA .The correlation was expressed by the Pearson′s correlation coefficient analysis.Multivariate linear regression analysis was performed to identify variables and influence factor associated with Hcy.Results The concentration of Urea in hypertensive high Hcy group (5.73 ± 1.67)mmol/L was significantly increased compared to normotensive normal Hcy group (4.79 ±1.05)mmol/L (t=3.508, P=0.001).The leve of Urea in hypertensive high Hcy group (5.73 ±1.67) mmol/L was significantly increased compared to normotensive high Hcy group (5.21 ±1.21) mmol/L ( t=1.983, P=0.049) and hypertensive normal Hcy group (4.81 ±1.21)mmol/L (t=3.600, P=0.000).The level of Crea in hypertensive high Hcy group ( 79.52 ±25.92 )μmol/L was significantly increased compared to normotensive normal Hcy group (58.39 ±12.83)μmol/L (t=6.121, P=0.000) and hypertensive normal Hcy group (60.93 ±13.74)μmol/L (t=5.526, P=0.000).The level of UA in hypertensive high Hcy group (389.96 ±96.03)μmol/L were significantly higher than normotensive normal Hcy group (293.65 ± 89.94)μmol/L (t=5.722, P=0.000),normotensive high Hcy group (327.02 ±66.55)μmol/L (t=3.837, P=0.000 ) and hypertensive normal Hcy group ( 291.50 ±73.42 )μmol/L ( t=6.128, P=0.000).The level of BMG,CysC in hypertensive high Hcy group and normotensive high Hcy group were higher than normotensive normal Hcy group and hypertensive normal Hcy group .The level of RBP ,D-Dimer, FDP in hypertensive high Hcy group were significantly higher than that of the other three groups .Serum homocysteine correlated positively with Urea (r=0.276,P=0.000),Crea(r=0.389,P=0.000),UA(r=0.339,P=0.000),BMG(r=0.221,P=0.002),RBP(r=0.396,P=0.000),CysC(r=0.200,P=0.006).Multivariate regression analysis showed that the Hcy level was the influencing factors of Urea , Crea and RBP, and hypertension was the influencing factor of Crea , UA, BMG RBP and CysC. Conclusions Hypertensive patients with hyperhomocysteinemia caused renal injury easily . Serum homocysteine may play an important role in renal injury and further affect the occurrence and development of hypertension by impairing the function of platelet , coagulation and fibrinolysis system .
