Effect of Intravenous Fat Emulsion on Glyphosate Surfactant Herbicide-Induced Shock in a Rat Model: A Preliminary Study.
- Author:
Byul Nim Hee CHO
1
;
Seung RYU
;
In Sool YOO
;
Hong Joon AHN
;
Gun Dong KIM
;
Hun KIM
Author Information
1. Department of Emergency Medicine, School of Medicine, Chungnam National University, Deajon, Republic of Korea. rs0505@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
Glyphosate;
Fat emulsions;
Intravenous;
Shock
- MeSH:
Anesthesia;
Animals;
Arterial Pressure;
Blood Pressure;
Catheterization;
Catheters;
Decontamination;
Models, Animal*;
Rats*;
Shock*
- From:Journal of the Korean Society of Emergency Medicine
2013;24(6):750-756
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Decontamination and supportive care are general types of treatment for glyphosate surfactant herbicide (GlySH) intoxication. However, no particular treatment for refractory shock has been established as a conventional therapy. Therefore, this study examined whether intravenous fat emulsion therapy (IFE) is effective on GlySH-induced shock. METHODS: This preliminary study was conducted on 10 rats. After anesthesia and catheterization, shock was induced by GlySH infusion. After a stabilization period, animals were randomized to receive intravenous normal saline (Group 1) or 20% lipid emulsion (Group 2). RESULTS: In the shock state, there was no significant difference between the two groups for systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP). In the post-management state, there was no significant difference between the two groups for SBP and MAP. However, there was a significant difference for DBP (Group 1, median 72.5 (IQR 52.8-74.6) mmHg; Group 2, median 77.6 (IQR 74.8-98.3) mmHg, p=0.016), SBP variation (Group 1, median 5.5 (IQR 1.6-11.1) mmHg; Group 2, median 25.6 (IQR 15.5-42.9) mmHg, p=0.008); DBP variation (Group 1, median -1.02 (IQR -4.69-11.0) mmHg; Group 2, median 21.1 (IQR 14.0-43.2) mmHg, p=0.008); MAP variation (Group 1, median 1.15 (IQR -2.6-11.0) mmHg; Group 2, median 23.2 (IQR 14.2-42.8) mmHg, p=0.008). CONCLUSION: The IFE increased blood pressure when shock was induced using GlySH. However, further studies are required to determine what components induced the shock and permitted a response to the IFE.
