Impact of perioperative mild hypothermia on neurological function and prognosis of patients with acute type A aortic dissection
10.3760/cma.j.issn.1001-4497.2018.11.004
- VernacularTitle:围手术期亚低温干预对急性A型主动脉夹层患者术后神经系统预后的影响
- Author:
Xiao SHEN
1
;
Cui ZHANG
;
Xiaochun SONG
;
Lei ZOU
;
Run FU
;
Xinwei MU
;
Liqiong XIAO
;
Fuhua HUANG
Author Information
1. 210000,南京医科大学附属南京医院 南京市第一医院重症医学科
- Keywords:
Mild hypothermia;
Acute type A aortic dissection;
Neurological function;
Prognosis
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2018;34(11):655-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of perioperative mild hypothermia on the neurological function and prog-nosis of patients with acute type A aortic dissection. Methods This study enrolled 65 patients with acute aortic dissection un-derwent surgery during the period of February 2017 to February 2018 and randomly divided them into mild hypothermia group and control group. After the process of deep hypothermic circulatory arrest,patients in the mild hypothermia group were re-warmed to 34 ℃ - 35 ℃ and maintained until 24 h after the operation. While,the patients in the control group were rewarmed to 36 ℃ and were treated with routine rewarm therapy. Baseline characteristics were recorded before the operation and neuro-logical and prognosis related indexes were recorded after the operation for all the patients. At the same time,peripheral venous bloods of all the patients were collected preoperatively and at 1、6、 12 and 24 h after the operation. Serum S 100β and neuron-specific enolase(NSE)levels were measured by ELISA kit. Results Compared with the control group,patients in the mild hypothermia group had a significantly shorter recovery time[ 10. 6 h(IQR:7. 6, 19. 1)vs. 25. 8 h(IQR: 13. 3,54. 2),P =0. 007]. At the same time,serum levels of NSE at 1 h and 6 h after operation and serum levels of S 100β levels at 1、6、 12 and 24 h after operation in the mild hypothermia group were significantly lower than those in the control group(P < 0. 05). In addi-tion,the length of stay in the mild hypothermia group was significantly shorter than that in the control group[ 19 days(IQR: 17, 23)vs. 24 days(IQR: 17,28),P = 0. 036]. However,there was no statistically difference in the incidence of delirium and cerebrovascular accidents between the two groups. Conclusion Perioperative mild hypothermia therapy can significantly re-duce brain cell damage in the patients with acute type A aortic dissection and can shorten postoperative recovery time and hospi-talization time,and thus improve the prognosis of patients.
