Recurrent late-onset group B Streptococcus sepsis in extremely preterm infant: a case report and literature review
10.3760/cma.j.issn.1007-9408.2019.01.010
- VernacularTitle:超早产儿复发性B族链球菌败血症一例并文献复习
- Author:
Wenyu LAI
1
;
Zhenbang ZHOU
;
Cunxin XU
;
Huali HUANG
;
Yanzhi YI
;
Jin YANG
Author Information
1. 香港大学深圳医院新生儿重症监护室 518053
- Keywords:
Bacteremia;
Streptococcal infections;
Streptococcus agalactiae;
Infant,extremely premature;
Infectious disease transmission,vertical
- From:
Chinese Journal of Perinatal Medicine
2019;22(1):46-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the controversial role of breast milk in late-onset group B Streptococcus (GBS) infections.Methods This study reported a case of recurrent late-onset GBS sepsis with the suspicion of breast milk transmission in an extremely preterm infant born at 22+6 weeks who was treated at the University of Hong Kong-Shenzhen Hospital in September 2016.Literatures about late-onset GBS cases associated with contaminated breast milk were reviewed to investigate whether GBS could be transmitted through breast milk.Results (1) Case report:A breast-fed extremely preterm infant born at 22+6 gestational weeks suffered from GBS sepsis along with meningitis for the first time on 100 d.The mother was negative for rectovaginal GBS screening.Breast milk wasn't tested as no signs of mastitis were found.The neonate recovered from the first GBS sepsis after 14 days of antibiotic treatment,then returned to breastfeeding.On 126 d,GBS sepsis reoccurred in this baby.Fresh breast milk culture yielded GBS which was identical with the GBS strains isolated from the neonatal blood in antimicrobial susceptibility.After recovery from the second episode,the baby was partially breastfed again without further relapses of late-onset GBS sepsis.(2) Literature review:64 cases of late-onset GBS infections that transmitted via breast milk were retrieved from PubMed,while no Chinese cases had been reported.Clinical data of the 65 cases (including this case) were reviewed and the results revealed that contaminated breast milk was associated with late-onset GBS infections.The reported relapse rate of GBS infections transmitted via breast milk was 25% for two episodes and 7% for three episodes.Conclusions GBS contaminated breast milk could potentially cause late-onset GBS sepsis in infants and further studies are required to identify the underlying mechanisms.