Research status on maternal pesticide exposure and offspring's risk of congenital heart disease

VernacularTitle:母亲孕期农药暴露对子代心脏发育影响的研究现状
Author: Yuanqing XIA ¹ ; Kena ZHAO ; Shenghui LI
Author Information

1. 200025,上海交通大学公共卫生学院
Keywords: Maternal exposure; Pesticides; Toxic actions; Heart defects,congenital; Fetus
From: Chinese Journal of Perinatal Medicine 2018;21(12):840-845
CountryChina
Language:Chinese
Abstract: We are interpreting the effects of maternal pesticide exposure during pregnancy on the heart development of offspring. Based on literature review till October 2018, 43 studies were included and three types of pesticide exposure (pesticides, herbicides and fungicides) were focused on. Our result show that maternal pesticide exposure during pregnancy could lead to an increased risk of congenital cardiovascular abnormalities in offsprings. Moreover, it is found that different types of pesticide exposure are associated with different subtypes of congenital heart disease. Generally and relatively, the evidence is consistent and strong for the following relationships: the associations of insecticide exposure with atrial septal defect, pulmonary valve stenosis and ventricular septal defects; the associations of herbicide exposure with transposition of the great arteries and ventricular septal defects; and the associations of bactericide exposure with hypoplastric left heart syndrome and aortic coarctation.