Acute kidney injury in donors of donation after brain plus cardiac death does not affect recipients' short-term prognosis in transplantation
10.3760/cma.j.issn.1001-7097.2019.01.004
- VernacularTitle:伴急性肾损伤的脑-心双死亡器官捐献供肾不影响移植受者短期预后
- Author:
Hanli HONG
1
;
Tongqing CHEN
;
Minwa LIN
;
Biqin XIE
;
Peiyi YE
;
Guanqing XIAO
;
Yaozhong KONG
Author Information
1. 佛山市第一人民医院肾内科
- Keywords:
Renal insufficiency;
acute;
Kidney transplantation;
Tissue and organ procurement;
Acute kidney injury;
Brain and cardiac death donors
- From:
Chinese Journal of Nephrology
2019;35(1):25-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of renal transplantation from donors of donation after brain and cardiac death(DBCD) complicated with acute kidney injury (AKI),and summarize the clinical experience of evaluation and application.Methods The clinical data of the 45 DBCD donors and 80 recipients in the First People's Hospital of Foshan from September 2011 to September 2015 were retrospectively analyzed.DBCD donors were classified into the AKI group (n=26) and non-AKI group (n=19) according to the serum creatinine level and urine output when the donors were admitted to the intensive care unit (ICU) in this hospital.A total of 80 recipients were divided into the AKI group (n=46) and non-AKI group (n=34) correspondingly.The condition of the donors before organ procurement between the two groups was compared,and the incidence of various complications,the 1 years survival rates of recipients and graft after renal transplantation were compared between the two groups.Results Among 45 donors,26 cases(57.8％) suffered from AKI.The serum creatinine of donors was significantly higher in the AKI group than that in the non-AKI group (P ＜ 0.01).The incidence of delayed graft function (DGF) in AKI group and non-AKI group was 21.7％ and 8.8％ respectively (P ＞ 0.05).After 1 years,the serum creatinine of the recipients in AKI group was significantly higher than that in non-AKI group [(134.9±63.4) μmol/L vs (106.6±28.2) μmol/L,P＜ 0.05],but the survival rates of recipients and grafts did no differ between the two groups (both P ＞ 0.05).Conclusions The donors combined with AKI do nothave a worse effect on the incidence of DGF,the 1-year survival rates of recipients and grafts after transplantation.So,the donors with AKI for transplantation can widen the origin of kidney grafts.
