Interpretation of National Institute on Aging-Alzheimer's Association research framework of biological definition of Alzheimer's disease 2018
10.3760/cma.j.issn.1006-7876.2019.02.016
- VernacularTitle:2018年美国国家衰老研究院-阿尔茨海默协会生物学定义阿尔茨海默病的研究框架解读
- Author:
Jing GAO
1
;
Chenhui MAO
;
Yupu GUO
Author Information
1. 中国医学科学院北京协和医院神经科 100730
- Keywords:
Alzheimer disease;
Biomarkers;
Alzheimer's continuum
- From:
Chinese Journal of Neurology
2019;52(2):157-160
- CountryChina
- Language:Chinese
-
Abstract:
The National Institute on Aging-Alzheimer's Association (NIA-AA) research framework of biological definition of Alzheimer's disease 2018 is introduced to Chinese counterparts to share a common "language" with dementia researchers.The abnormal definitions of Alzheimer's disease (AD),βamyloid deposition (Aβ) and tau,were proposed to be detected by biological methods,and a series of changes before dementia and dementia were proposed to be studied under a unified biological framework.The characteristic biomarkers were defined as AT(N):A is [β amyloid deposition,T is pathological tau protein,and (N) is neurodegeneration.The diversity of the pathological nature of dementia was emphasized,and AD combined with dementia was proposed not to be directly attributable to dementia due to AD.The definition of biomarkers requires more standardization and confirmation of autopsy pathology.
