Progress in research on the role of cannabinoid receptor signaling pathway in Huntington's disease
10.3760/cma.j.issn.1006-7876.2019.02.014
- VernacularTitle:大麻素受体信号通路在亨廷顿病中作用的研究进展
- Author:
Shiyu ZHU
1
;
Yongli LU
;
Hongwei YANG
Author Information
1. 三峡大学医学院生理与病理生理学系
- Keywords:
Huntington's disease;
Cannabinoid receptor 1;
Brain derived neurotrophic factor;
Neuropeptide Y
- From:
Chinese Journal of Neurology
2019;52(1):67-70
- CountryChina
- Language:Chinese
-
Abstract:
Huntington's disease (HD),a single-gene autosomal dominant neurodegenerative disease,is pathologically characterized by the great loss of striatal neurons in the brain.Clinical manifestations of HD show involuntary dance-like movements,cognitive function and neuropsychiatric symptoms.The pathogenesis of HD is concerned with the protein expression of mutant huntingtin which leads to the selective degeneration of medium spiny neurons in the striatum and the onset of the disease.Cannabinoid receptor (CBR) plays a key role in the release of neurotransmitters,synaptic plasticity,gene expression and modulation of.neuronal activity through the CBR1 and CBR2 signaling pathways.Recent studies have found that CBR-mediated phosphoinositide3-kinases/protein kinase B/mammalian target of rapamycin complex1/brain derived neurotrophic factor,neuropeptide Y/neuronal nitric oxide synthase signaling pathway play a vital role in the regulation.of striatal neuroprotection in HD.This review reveals the research progress of CBR1 related signaling pathways in HD,which provides new theoretical basis and drug targets for the prevention and treatment of HD.
