Detection of monosodium urate crystals with dual-energy CT in gout patients
10.3760/cma.j.issn.1671-7368.2019.01.012
- VernacularTitle:双能CT成像技术检测尿酸盐结晶对痛风诊断的临床价值研究
- Author:
Dong TANG
1
;
Xiaoman WANG
;
Le QI
;
Dongmei WANG
Author Information
1. 杭州师范大学附属医院放射科 310015
- Keywords:
Radiography,dual-energy scanned projection;
Gout;
Arthritis,gouty;
Crystallization,uric acid
- From:
Chinese Journal of General Practitioners
2019;18(1):52-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application of the dual-energy CT (DECT) in detection of monosodium urate (MSU) crystals in gout patients.Methods The imaging and clinical data of 101 patients with suspected gout were retrospectively analyzed,including 64 cases of clinically diagnosed gout (gout group) and 37 non-gout cases (non-gout group).The DECT examination was performed for 85 joints in gout group and 42 joints in non-joint group.The value of DECT in detection of MSU crystals was evaluated with receiver operating characteristic (ROC) curve.Results There were significant differences in gender (x2=5.32,P=0.03) and blood uric acid levels (t=1.95,P=0.04) between gout and non-gout groups.The detection rate of MSU in gout group was significantly higher than that of non-gout group (x2=30.52,P＜0.001).The area under the ROC curve (AUC) of DECT in detection of was 0.74±0.05 (Mean±SE),95％CI:0.64-0.85.The sensitivity,specificity,positive predictive value and negative predictive value of the DECT in detection of gouty stone was 0.844,0.703,83.1％ and 72.2％,respectively.Conclusion The dual-energy CT has high sensitivity,specificity and reliability for the detection and diagnosis of monosodium urate crystals in joints of gout patients.
