Efficiency and safety of simultaneous resection vs staged resection on in colorectal carcinoma with synchronous liver metastasis:a meta-analysis
10.3760/cma.j.issn.1007-631X.2018.11.008
- VernacularTitle:同时性结直肠癌肝转移同期与分期手术切除疗效与安全性的Meta分析
- Author:
Kai CHEN
1
;
Hongji YANG
Author Information
1. 四川省医学科学院四川省人民医院器官移植中心
- Keywords:
Colorectal neoplasms;
Neoplasm metastasis
- From:
Chinese Journal of General Surgery
2018;33(11):924-929
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the safety and efficiency between simultaneous resection and staged resection of synchronous colorectal liver metastases.Methods A systematic literature search was performed in PubMed,Embase,Cochrane Library,OVID,Web of Science,WanFang Data,CBM,VIP and CNKI databases for relevant articles published from January 2000 to July,2017.The meta-analysis was performed by RevMan 5.3.The primary outcomes were peri-operative complications,postoperative mortality,five-year survival rate.Results 25 studies with a total of 5 631 patients were finally included.The results of meta-analysis showed that simultaneous and staged resections were similar in peri-operative complications (OR =0.90,P =0.39),postoperative mortality (OR =1.23,P =0.29) and five-year survival rate (OR =1.03,P =0.68).Conclusions Simultaneous resection is safe and efficient in the treatment of patients with SCLMs.However,the results should be interpreted and applied prudently due to the lower level of evidence and the existence of heterogeneity.
