Mas-related G protein-coupled receptor X2: a novel receptor for non-IgE-dependent activation of mast cells
10.3760/cma.j.issn.0412-4030.2019.02.021
- VernacularTitle:肥大细胞非IgE途径活化新型受体mas相关G蛋白偶联受体X2的研究进展
- Author:
Anwei CHEN
1
;
Xiaoming BAI
;
Hua WANG
Author Information
1. 重庆医科大学附属儿童医院皮肤科儿童发育疾病研究教育部重点实验室儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室 400014
- Keywords:
Mast cells;
Immunoglobulin E;
Receptors,G-protein-coupled;
Pruritus
- From:Chinese Journal of Dermatology
2019;52(2):142-144
- CountryChina
- Language:Chinese
-
Abstract:
Mast cells (MC),a major participant in inflammation and allergy,can initiate an early defense response to foreign invaders.Besides expressing high-affinity IgE receptor,MC also expresse a large number of G protein-coupled receptors (GPCRs).Various studies have shown that cationic micromolecules represented by substance P and many peptidergic drugs can induce MC degranulation through a novel receptor,Mas-related G protein-coupled receptor X2 (MrgprX2).MrgprX2 plays an important role in allergy,itching and pseudo-allergic drug reactions.It will help explain some clinical difficulties which can not be explained by classical IgE-dependent activation of MC,and provides potential therapeutic targets for MC-mediated diseases.
