Efficacy of single-session plasmapheresis therapy alone for the treatment of toxic epidermal necrolysis in 17 cases: a clinical observation
10.3760/cma.j.issn.0412-4030.2018.12.010
- VernacularTitle:单纯单次血浆置换疗法治疗17例中毒性表皮坏死松解症临床观察
- Author:
Feng HAN
1
;
Jingjing ZHANG
;
Yanli HOU
;
Xiaopeng WANG
;
Jingang AN
;
Xiaochuang WANG
;
Manxiang LI
;
Gang WANG
Author Information
1. 710004,西安交通大学第二附属医院重症医学科
- Keywords:
Epidermal necrosis,toxic;
Plasma exchange;
Treatment outcome
- From:
Chinese Journal of Dermatology
2018;51(12):896-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of single-session plasmapheresis therapy alone for the treatment of toxic epidermal necrolysis (TEN),and to investigate its adverse reactions.Methods Patients with TEN receiving single-session plasmapheresis therapy alone were collected from the Second Affiliated Hospital of Xi'an Jiaotong University between September 2010 and December 2017.Clinical data on the disease severity,clinical efficacy,hospitalization duration and adverse reactions were analyzed.Results A total of 17 patients with TEN were enrolled into this study,including 9 males and 8 female,with an average age of 36.1 ± 25.4 years.Their initial SCORTEN and STENS scores were 2.1 ± 1.24 and 29.9 ± 6.6 respectively.After treatment,the STENS score decreased to 3.5 ± 1.8.Of the 17 patients,15 were cured after single-session plasmapheresis therapy,1 showed response to the treatment,and 1 died.The duration of intensive care unit stay was 6.4 ± 1.8 days,and the total hospitalization duration was 12.1 ± 5.7 days.There was no significant difference in the STENS score among the day 1,4,7,10 and 20 after hospital admission (F =18.569,P ＜ 0.05).No severe adverse reactions were observed,except 2 cases of plasma allergy.Conclusion Single-session plasmapheresis therapy alone is effective for the treatment of TEN without obvious adverse reactions.
