Correlations between gastric Helicobacter pylori infection and colorectal polyps or cancer
10.3760/cma.j.issn.0578-1426.2019.02.011
- VernacularTitle:幽门螺杆菌感染与结直肠息肉及结直肠癌的相关性分析
- Author:
Yifan DONG
1
;
Tao GUO
;
Hong YANG
;
Jiaming QIAN
;
Jingnan LI
Author Information
1. 中国医学科学院北京协和医学院北京协和医院消化内科 100730
- Keywords:
Helicobacter pylori;
Colorectal neoplasms;
Colorectal polyps
- From:
Chinese Journal of Internal Medicine
2019;58(2):139-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations between gastric Helicobacter pylori (Hp) infection and colorectal polyps or cancer.Methods Among patients who finished colonoscopy exams in Peking Union Medical College Hospital (PUMCH) between May 2012 and May 2017,3 483 patients were diagnosed with colorectal polyps,135 patients with newly diagnosed colorectal cancer.A total of 1 925 healthy subjects were enrolled as normal controls.Gastric rapid urease tests (RUT) were done in all patients.General clinical data,RUT results,sizes and numbers of polyps,cancer location were analyzed.Results The proportion of Hp infection in patients with colorectal polyps was 31.5％,higher than that in healthy controls.The odds ratio (OR) of Hp infection in polyp group was 1.17 (95％CI 1.04-1.32) after age and gender were adjusted.The Hp infection rate in patients with polyps over or equal to 1 cm was significantly higher than that in patients with polyps smaller than 1 cm.Patients with more than 1 polyps presented a higher rate of Hp infection than patients with only 1 polyp.Hp infection rate in patients with colorectal cancer was 36.3％,with the adjusted OR 1.56 (95％CI 1.06-2.30).The location of colorectal cancer was not correlated with Hp infection.Conclusions Gastric Hp infection is more common in patients with colorectal polyps than in healthy controls.Polyps ≥1 cm,multiple polyps and colorectal cancer are correlated with higher rates of Hp infection.Cancer location is irrelevant to Hp infection.
