The diagnostic framework for screening Alzheimer's disease in the Chinese population
10.3760/cma.j.issn.0578-1426.2019.02.005
- VernacularTitle:适用于中国人群的阿尔茨海默病筛查和诊断框架
- Author:
Jinzhou TIAN
1
;
Hengge XIE
;
Bin QIN
;
Dongsheng FAN
;
Jing SHI
;
Weizhong XIAO
;
Jingnian NI
;
Mingqing WEI
;
Tao LU
;
Luning WANG
;
Yinhua WANG
Author Information
1. 北京中医药大学东直门医院脑病科 100700
- Keywords:
Dementia;
Alzheimer's disease;
Screening and diagnostic;
Framework
- From:
Chinese Journal of Internal Medicine
2019;58(2):91-101
- CountryChina
- Language:Chinese
-
Abstract:
Criteria for diagnosis of Alzheimer's disease (AD) is not available in China.The international criteria is not a proper choice due to issues such as translation and lead to low diagnostic rate and high rate of missed diagnosis.The research group of Alzheimer's Disease Chinese (ADC) reviewed knowledge and techniques in neuropsychology,neuroimaging,molecular biology,and clinical neurology,and systematically studied the detection techniques such as memory,language,visuospatial,executive function,and medial temporal lobe visual scores on MRI,and their optimal threshold and diagnostic value for the diagnosis of AD.Through a systematic review and consensus meeting,a diagnostic framework for screeningAD in the Chinese population was established.Among these methods,an operational standard for clinical pathology models increased the diagnostic sensitivity by 15％.The sensitivity and specificity of screening memory impairment increased by 18.1％ and 11.6％,respectively.The sensitivity of screening medialtemporal lobe atrophy increased by 24.5％ and missed diagnosis was decreased by 34.5％.An operational standard for clinical biology models,incorporating the latest molecular imaging and molecular biology techniques,has enabled the early diagnosis of AD in China.The framework combines a principled diagnostic guideline with an operational screening protocol,which is applicable to all clinical settings and of great significance for the early detection,early diagnosis and early treatment of AD.
