Approach to the management of hypothalamic pituitary function in patients with craniopharyngioma after operation
10.3760/cma.j.issn.1000-6699.2018.12.011
- VernacularTitle:颅咽管瘤术后下丘脑垂体功能管理的临诊应对
- Author:
Jing SUI
1
;
Peijie SHI
;
Hui GUO
;
Mingqian HE
;
Bingyin SHI
Author Information
1. 710061,西安交通大学第一附属医院内分泌科
- Keywords:
Craniopharyngioma;
Hypopituitarism;
Diabetes insipidus;
Hypothalamic obesity;
Treatment
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(12):1042-1047
- CountryChina
- Language:Chinese
-
Abstract:
Craniopharyngiomas develop from remnant epithelial cells of Rathke's pouch in the sella/parasella region with low histological grade. Clinical manifestations are related to visual impairment, increased intracranial pressure, and hypothalamic/pituitary deficiencies, including vision loss, headache, nausea, growth retardation, and hypogonadism. Despite benign epithelial tumors, craniopharyngiomas are adjacent to critical brain structures including hypothalamus, pituitary stalk, chiasma opticum and have recurrence tendency. Treatment-related complications including hypothalamic/pituitary deficiencies, diabetes insipidus, and hypothalamic obesity are major risk factors for reduced quality of survival and throw out a great challenge to the surgical treatment and the postoperative management. Clinical features of one case craniopharyngiomas with manifestation of severe hypopituitarism are described with the aim of exploring effective therapies.
