Assessing the clinical risk factors of fragility fractures with GWAS data and Mendelian randomisation approach

VernacularTitle:以GWAS大数据为基础的孟德尔随机化方法探索脆性骨折的临床风险因素
Author: JinJian XU ¹ ; Jiangwei XIA ; Houfeng ZHENG
Author Information

1. 311121,杭州师范大学衰老研究所
Keywords: Fracture; Bone mineral density; Genome wide association study; Mendelian randomization
From: Chinese Journal of Endocrinology and Metabolism 2018;34(12):987-991
CountryChina
Language:Chinese
Abstract: This commentary on the paper " Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study" published recently on the British Medrcal Journal (BMJ), has been focused on the analysis of the study design and the advantages/disadvantages of large-scale design. Besides discussing the main findings of the study, it is pointed out that the negative relationship between the traits should be interpreted carefully. Finally, we introduce the study design of Mendelian randomization ( MR) and randomized controlled trial (RCT), the similarities and differences between them are compared. We believe that more and more MR studies based on large-scale genome wide association study (GWAS) data will be carried out in the next few years.