Expression of Intercellular Adhesion Molecule-l (ICAM-1) in Vascular Endothelium and Keratinocytes of Psoriatic Skin.
10.5021/ad.2000.12.4.259
- Author:
Dea Hyun BAN
;
Sang Wahn KOO
;
Young Keun KIM
;
Gwang Seong CHOI
;
Joo Heung LEE
- Publication Type:Original Article
- Keywords:
Psoriasis;
Intercellular adhesion molecule-1 (ICAM-1)
- MeSH:
Dermis;
Endothelial Cells;
Endothelium;
Endothelium, Vascular*;
Epidermis;
Humans;
Intercellular Adhesion Molecule-1;
Keratinocytes*;
Lymphocytes;
Membranes;
Memory;
Microvessels;
Psoriasis;
Skin*;
T-Lymphocytes;
Up-Regulation
- From:Annals of Dermatology
2000;12(4):259-263
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The endothelial expresson and upregulation of ICAM-1 and epidermal keratinocyte expression of ICAM-1 are well documented in psoriasis. ICAM-1 mediates the adhesion and trafficking of circulating activated skin-seeking CD45RO+ memory CD4+ T lymphocytes from the vessel into the dermis and epidermis of psoriatic skin by binding to its ligand LFA-1(lymphocyte function-associated antigen-1) expressed on lymphocyte membranes. OBJECTIVE: The purpose of this study was to investigate the expression of ICAM-1 in vascular endothelium and keratinocyte of psoriatic skin and the difference of ICAM-1 expression between early and fully developed psoriatic lesions. METHODS: We have studied the expression of ICAM-1 in twelve psoriatic patients who had not been treated for psoriatic lesions for 1 month and three normal human skin samples by immunohistochemical staining using monoclonal antibody against ICAM-1. RESULTS: Immunohistochemical staining revealed anti-ICAM-1 antibody positively stained only in the subpapillary endothelial cells of normal skin. But in all psoriatic lesions studied, anti- ICAM-1 antibody was stained positively in the endothelium of papillary and subpapillary plexus, and in fully developed psoriatic lesions, anti-ICAM-1 antibody was stained focally in epidermal keratinocytes. CONCLUSION: The results suggest that ICAM-1 expression on papillary microvessels and keratinocytes may play an important role in the transendothelial and transepidermal migration of lymphocytes from the vessel into the dermis and epidermis of psoriatic skin.
