Comparison of effects of propofol and sevoflurane on oxidative stress responses in patients undergo-ing one-lung ventilation
10.3760/cma.j.issn.0254-1416.2018.08.022
- VernacularTitle:丙泊酚和七氟醚对单肺通气患者氧化应激反应影响的比较
- Author:
Yingjie TIAN
1
;
Lijun YIN
;
Xuejun CHEN
;
Yonghao YU
;
Keliang XIE
Author Information
1. 301800,天津医科大学宝坻临床学院
- Keywords:
Propofol;
Anesthetics,inhalation;
Respiration,artificial;
Stress
- From:
Chinese Journal of Anesthesiology
2018;38(8):981-984
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of propofol and sevoflurane on oxidative stress re-sponses in patients undergoing one-lung ventilation. Methods Eighty American Society of Anesthesiolo-gists physical statusⅠorⅡpatients with lung cancer, aged 42-53 yr, weighing 52-83 kg, scheduled for e-lective pulmonary lobectomy performed via a thoracoscope, were divided into 2 groups ( n=40 each) using a random number table method: group propofol and group sevoflurane. Propofol was intravenously infused at 4-10 mg·kg-1 ·h-1 in group propofol. In group sevoflurane, 1％-3％ sevoflurane was inhaled. Forced expiratory volume (FEV), forced vital capacity (FVC), FEV in first second (FEV1), FEV∕FVC, and maximal expiratory flow ( MEF) were measured at 24 h after operation. Blood samples were obtained from the median cubital vein for determination of the levels of plasma malondialdehyde ( MDA) , catalase ( CAT) and superoxide dismutase ( SOD) and expression of NOX2 and NOX4 subunits-containing NADPH oxidase, SP-D and CC16 ( by Western blot) . Results Compared with group sevoflurane, FEV, FVC, FEV1, FEV∕FVC and MEF were significantly increased, the activity of plasma SOD and CAT was increased, MDA con-centration was decreased, the expression of NOX2 and NOX4 subunits-containing NADPH oxidase and SP-D was down-regulated, and the expression of CC16 was up-regulated in group propofol (P<0. 05). Conclu-sion Propofol provides better efficacy in protecting lung function of patients undergoing one-lung ventilation when compared with sevoflurane, which is related to inhibiting oxidative stress responses.
