Effect of aminophylline on efficacy of extubation under ultra-fast track anesthesia in pediatric pa-tients with congenital heart disease undergoing surgical correction of anomaly
10.3760/cma.j.issn.0254-1416.2018.08.019
- VernacularTitle:氨茶碱对先天性心脏病矫治术患儿超快通道麻醉气管拔管效果的影响
- Author:
Chaobin ZHANG
1
;
Yuan JIA
;
Rong WANG
;
Li SUN
;
Fuxia YAN
Author Information
1. 100021,国家癌症中心 中国医学科学院 北京协和医学院 肿瘤医院麻醉科
- Keywords:
Aminophylline;
Heart defects,congenital;
Anesthesia;
Trachea
- From:
Chinese Journal of Anesthesiology
2018;38(8):969-972
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of aminophylline on the efficacy of extubation under ultra-fast track anesthesia ( UFTA) in pediatric patients with congenital heart disease ( CHD) undergoing surgical correction of anomaly. Methods Ninety American Society of Anesthesiologists physical status Ⅰor Ⅱ pediatric patients, aged<6 yr, undergoing surgical correction of anomaly, were randomized into 3 groups ( n=30 each) using a random number table method: group Ⅰ, group Ⅱ and group Ⅲ. After the end of surgery, normal saline was given in groupⅠ, 1 mg∕kg aminophylline was given in groupⅡ, and 2 mg∕kg aminophylline was given in groupⅢ. The condition of extubation in the operating room and respirato-ry rate at extubation were recorded. Mean arterial pressure, heart rate and bispectral index value were re-corded at the end of surgery, and at 9 and 15 min after administration. Results Compared with groupⅠ, the rate of successful extubation in the operating room, BIS value at 9 min after administration and respira-tory rate at extubation were significantly increased inⅡand Ⅲ groups ( P<0. 05) . There was no significant difference in the parameters mentioned above between group Ⅱand group Ⅲ ( P>0. 05 ) . Conclusion Aminophylline can increase the efficacy of extubation under UFTA in pediatric patients with CHD undergoing surgical correction of anomaly, and 1 mg is the recommended dose.
