Comparison of efficacy of adriamycin chemo-ganglionectomy and radiofrequency thermocoagulation of gasserian ganglionin in treating craniofacial postherpetic neuralgia
10.3760/cma.j.issn.0254-1416.2018.08.010
- VernacularTitle:半月神经节阿霉素化学损毁术与射频热凝术对头面部带状疱疹后遗神经痛疗效的比较
- Author:
Jingzhi LIU
1
;
Kemei SHI
;
Wenting MA
;
Quanbo LI
;
Qiang FU
;
Gang SHENG
;
Baosen ZHENG
Author Information
1. 300211,天津医科大学第二医院疼痛治疗中心
- Keywords:
Neuralgia,postherpetic;
Doxorubicin;
Electrocoagulation;
Trigeminal ganglion
- From:
Chinese Journal of Anesthesiology
2018;38(8):933-936
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of adriamycin chemo-ganglionectomy and radiofre-quency thermocoagulation ( RFT ) of semilunar ganglion in treating craniofacial postherpetic neuralgia ( PHN) . Methods A total of 95 patients with PHN in the areas innervated by maxillary and mandibular divisions of trigeminal nerve, aged 55-90 yr, with the course of disease 6 months-3 yr, were divided into 2 groups using a random number table method: adriamycin chemo-ganglionectomy group ( ADM group, n=48) and RFT group ( n=47) . Hartel anterior approach to puncture was performed via the foramen ovale un-der the guidance of CT in two groups. In group ADM, 0. 5％ adriamycin 2. 5 mg ( 0. 5 ml) was injected via the foramen ovale, and RFT of gasserian ganglion was performed in group RFT. Visual Analog Scale (VAS) and the short-form McGill pain questionnaire (SF-MPQ) scores were evaluated before and after treatment. The rate of effective treatment was calculated, and treatment-related complications were recor-ded. Results Compared with group RFT, no significant change was found in VAS or SF-MPQ scores be-fore treatment, VAS and SF-MPQ scores were increased and the rate of effective treatment was decreased at 1 and 7 days after treatment, VAS and SF-MPQ scores were decreased and the rate of effective treatment was increased at 6 and 12 months after treatment, the incidence of facial numbness, hypoesthesia, masti-catory muscle weakness and weakened corneal reflex was decreased in group ADM ( P<0. 05) . Conclusion Compared with semilunar ganglion RFT, the long-term efficacy of adriamycin chemo-ganglionectomy of semilunar ganglion in treating craniofacial PHN is enhanced, and the safety is higher.
