Changes in serum brain-derived neurotrophic factor levels in patients with Alzheimer's disease
10.3760/cma.j.issn.0254-9026.2019.02.009
- VernacularTitle:老年阿尔茨海默病患者血清脑源性神经营养因子水平的变化
- Author:
Chong ZHANG
1
;
Wei GUO
;
Yun YANG
;
Deyou QIN
;
Xiaoming LIAO
Author Information
1. 桂林医学院第二附属医院神经内科 541000
- Keywords:
Alzheimer disease;
Cognition disorders;
Brain-derived neurotrophic factor
- From:
Chinese Journal of Geriatrics
2019;38(2):151-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate changes in serum brain-derived neurotrophic factor (BDNF)levels in patients with Alzheimer's disease(AD).Methods Venous blood samples were collected from 40 AD patients,40 amnestic mild cognitive impairment(aMCI)patients and 40 normal controls.Serum BDNF levels were analyzed by enzyme-linked immunosorbent assay (ELISA).The relationships of serum BDNF levels with age,gender,educational level,mini-mental state examination (MMSE) score and Beck depression scale-Ⅱ (BD Ⅰ-Ⅱ)score in AD patients were analyzed.Results Serum BDNF levels were lower in AD patients than in patients with aMCI and normal controls(4.6± 1.9 μg/L vs.9.3 ± 4.7 μg/L,10.2 ± 1.8 μg/L,F =71.083,P ＜0.05).There were 12 mild AD patients,18 moderate AD patients and 10 severe AD patients,and serum BDNF levels decreased with increased disease severity(5.5±5.4 μg/L,4.9±4.2 μg/L vs.3.8±3.0 μg/L,F=78.214,P＜0.05).Serum BDNF levels decreased in 29 AD patients aged over 65 years compared with 11 AD patients aged 65 years and younger(3.6±2.2 μg/L vs.4.64±1.06 μg/L,P＜0.05).Serum BDNF levels had no correlation with gender,educational level or BD Ⅰ-Ⅱ score(P＞0.05).Pearson correlation analysis showed that serum BDNF levels had a positive correlation with MMSE score(r =0.428,P＜0.05).Conclusions Advanced age is associated with decreased serum levels of BDNF in AD patients.Decreased serum levels of BDNF in AD patients are related to the severity of cognitive impairment.There is no correlation between serum BDNF levels and depressive symptoms in AD patients.
