Investigation of the frequency and location of cerebral microbleeds in dementia with Lewy bodies versus in Alzheimer's disease
10.3760/cma.j.issn.0254-9026.2019.02.008
- VernacularTitle:阿尔茨海默病和路易体痴呆患者脑微出血的临床特点
- Author:
Maomao LIU
1
;
Jinghuan GAN
;
Shuai LIU
;
Wenzheng HU
;
Yujin ZHAO
;
Zhanglong LI
;
Yong JI
Author Information
1. 北京首都医科大学附属北京天坛医院神经病学中心
- Keywords:
Alzheimer disease;
Dementia;
Lewy body disease;
Cerebral hemorrhage
- From:
Chinese Journal of Geriatrics
2019;38(2):147-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the frequency and location of cerebral microbleeds(CMB) in dementia with Lewy bodies(DLB)versus in Alzheimer's disease(AD).Methods This retrospective study included three groups of probable AD patients (n =156),dementia with Lewy bodies (n =67) and normal controls(n=172).Frequencies and location of CMBs in the three groups were calculated and recorded.The foci of MRI signal for CMB were confirmed by two radiologists at moments of unknowingness about diagnosis.The correlations of cerebral small vessel disease and cerebral amyloid angiopathy with the development of cognitive decline in AD were analyzed.Results The incidence rate of CMBs was higher in patients with groups of DLB(22.4 ％,15/67) and AD(19.8 ％,31/156) than in normal controls (8.2 ％,14/172) (P =0.002 and 0.002),while there was no significant difference in incidence rate of CMBs between DLB and AD groups(P＞0.05).The MRI signal intensity of CMBs was the highest in the occipital lobe of the DLB group,and was higher in the deep temporal lobe or temporal lobe in the AD group.Conclusions The frequency of CMB is higher in patients with DLB or AD than in normal controls and there is no significant difference in frequency of CMB between DLB and AD groups,which suggests that the pathophysiological mechanisms of CMB may be similar between AD and DLB.
