Association between frailty and serum biomarkers in older adults
10.3760/cma.j.issn.0254-9026.2018.12.022
- VernacularTitle:老年人衰弱与血液生物指标的关系研究
- Author:
Hong SHI
1
;
Li MENG
;
Jing SHI
;
Daguang WANG
;
Cong SHAO
;
Jing PANG
;
Guoqing FAN
;
Yuefan LI
;
Shuai ZHANG
;
Yuetao ZHAO
;
Xue LI
;
Jing LI
;
Xin ZHAO
;
Tiemei ZHANG
;
Chunbo DUAN
;
Pulin YU
;
Huan XI
Author Information
1. 100730,北京医院老年医学科国家老年医学中心
- Keywords:
Frailty;
Biomarkers;
Inflammation;
Insulin-like growth factor;
Homocysteine;
25(OH)D;
Folate
- From:
Chinese Journal of Geriatrics
2018;37(12):1383-1386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between frailty and serum biomarkers in the elderly. Methods A total of 371 elderly individuals aged 60 years and above with complete medical data were recruited during health examinations. Frailty phenotype assessment and comprehensive geriatric assessment were conducted.Serum levels of interleukin-6 (IL-6 ) ,high sensitivity C-reactive protein(hs-CRP) ,tumor necrosis factor-α(TNF-α) ,homocysteine(Hcy) ,insulin-like growth factor-1(IGF-1) ,25-hydroxyvitamin D[25(OH)D] ,folic acid and vitamin B12(VitB12) were detected by enzyme-linked immunosorbent assays ( ELISA ) and chemiluminescence immunoassays. Associations between frailty and the above factors were analyzed. Results Serum levels of IL-6 ,TNF-α ,Hcy and IGF-1 were significantly elevated along with progressive increase in frailty severity(all P＜0.05).There were a downward trend in serum 25(OH)D levels and an upward trend in serum hs-CRP ,folic acid and VitB12 levels as frailty severity increased ,but the changes did not amount to any statistical significance(all P＞0.05).Logistic regression analysis showed that ,after adjusting for age ,gender ,body mass index (BMI)and some clinical aspects (hearing loss ,urinary incontinence ,pain ,malnutrition ,cognitive dysfunction ,decreased activities of daily living ,depression , insomnia ,and anemia) ,serum levels of IL-6(OR=1.012 ,95% CI=1.005-2.041 ,P=0.033) ,IGF-1 (OR= 1.017 ,95% CI = 1.011-1.118 ,P= 0.021)and Hcy (OR= 1.007 ,95% CI :1.002-1.073 ,P=0.047)were significantly associated with frailty status. Conclusions Serum levels of IL-6 ,Hcy and IGF-1 are related to frailty status and may be used as potential biomarkers for the assessment of frailty in older adults.
