Research progress on drug-resistance of influenza virus to neuraminidase inhibitors

VernacularTitle:流感病毒对神经氨酸酶抑制剂耐药性的研究进展
Author: Jiaqi BAO ^{1
,

2} ; Xiaochen WANG ; Qianda ZOU ; Shufa ZHENG ; Yu CHEN
Author Information

1. 310003 杭州,浙江大学医学院附属第一医院检验科
2. 310002 杭州,浙江省临床体外诊断技术研究重点实验室
Keywords: Influenza A virus; Influenza B virus; Influenza C virus; Neuraminidase inhibitors; Drug-resistance; Mutation
From: Chinese Journal of Clinical Infectious Diseases 2018;11(6):473-480
CountryChina
Language:Chinese
Abstract: Influenza virus , the causative agent of influenza , has characteristics of fast transmission and strong infectivity, posing a major threat to public health .Currently, with widely use of the first-line antiviral neuraminidase inhibitors , drug-resistant strains have appeared and brought difficulties to the precaution and treatment of influenza .This article reviews influenza virus structural characteristics , drug-resistance mechanisms , resistance situation and detection methods of drug-resistant virus strains , aiming to provide a reference for future research on influenza virus drug-resistance and clinical medication .