Efficacy analysis of CT-guided 125I seeds implantation combined with chemotherapy in the treatment of unresectable non-small cell lung cancer
10.3760/cma.j.issn.2095-2848.2019.02.008
- VernacularTitle:CT引导125I粒子植入联合化疗对不可切除非小细胞肺癌的疗效分析
- Author:
Jiali ZOU
1
;
Wu LU
;
Peng CHEN
;
Changxiang SONG
;
Yong LIU
;
Xiaoshuai YUAN
;
Peng DU
Author Information
1. 南京医科大学连云港临床医学院核医学科 222002
- Keywords:
Carcinoma,non-small-cell lung;
Brachytherapy;
Iodine radionuclide;
Tomography,X-ray computed;
Drug therapy,combination
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(2):96-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of CT-guided 125I seeds implantation combined with gemcitabine + cis-platinum (GP) in the treatment of unresectable non-small cell lung cancer (NSCLC).Methods From January 2013 to January 2017,62 patients with unresectable Ⅱ b-Ⅲb NSCLC were randomly divided into 2 groups.In the study group,32 patients (17 males,15 females,age (62.7± 8.9) years) underwent 125I seeds implantation combined with 4 courses of GP chemotherapy,and 30 patients (18 males,12 females,age (61.9±7.0) years) in the control group underwent concurrent radiotherapy combined with 4 courses of GP chemotherapy.The short-term effects at 3 and 6 months after treatment were compared between 2 groups,as well as the survival time.Log-rank test was used to analyze the data.Results The effective rates at 3 and 6 months after treatment in the study group and control group were statistically significant (90.62％ (29/32) vs 70.00％ (21/30),96.88％ (31/32) vs 66.67％ (20/30);x2 values:3.00 and 7.22,both P＜0.05).The median survival time of the study group and control group were 17 and 15 months (x2 =2.194,P＞0.05).The 1-year survival rates of 2 groups were 87.50％ (28/32) and 76.67％ (23/30),respectively (x2=1.24,P＞0.05),and the 2-year survival rates were 40.62％ (13/32)and 20.00％(6/30),respectively (x2=4.00,P＜0.05).Conclusions 125I seeds implantation combined with GP chemotherapy is a significant treatment for unresectable NSCLC.The short-term efficacy is better than concurrent radiotherapy combined with GP regimen.
